What Is NAC | How Does NAC Work | Benefits | Is NAC Banned |ย Popular Products | Warnings And Side Effects |ย Disclaimer
The health and wellness industry has been giving significant attention to N-Acetyl Cysteine (NAC) due to its potential therapeutic benefits. From respiratory health to mental well-being, studies on NAC suggest it provides a wide and diverse range of applications and is increasingly being added to supplement regimens. If youโre curious about N-Acetyl Cysteine and how it can help you, youโve come to the right place. In this blog post, we will dive into what NAC is, how it works, its benefits, and other common questions!
What Is NAC?
N-Acetyl Cysteine (NAC) is a compound that plays a crucial role in supporting various bodily functions. Itโs a type of amino acid that is also a precursor of L-cysteine, a semi-essential/conditionally essential amino acid. (1)
There are 20 amino acids that make up proteins in the human body. These amino acids are categorized by their biosynthesis processes as essential, semi-essential, or nonessential. Out of 20, only nine amino acids comprise the essential amino acid group.ย These amino acids cannot be synthesized in our bodies, meaning we need to supplement them in our diets. Meanwhile, semi-essential amino acids, like cysteine, typically run low during infancy or when sick/injured. Therefore, the remaining amino acids and non-essential can be synthesized in the body. (2) Similar to L-cysteine, NAC is a precursor for another compound, glutathione, a potent antioxidant. (3)ย
How Does NAC Work?
NAC exerts its effects through various mechanisms within the body. As a precursor to glutathione, NAC helps increase glutathione levels, enhancing the bodyโs antioxidant capacity and supporting cellular health. This supports your body in neutralizing free radicals that can damage cells and tissues. (3) Additionally, NAC may help modulate glutamate, an important neurotransmitter in the brain. It helps regulate the balance of glutamate by promoting its conversion to glutamine, an inactive form. (4)
Outside of its influence on other compounds, NAC possesses its own direct antioxidant activity. It scavenges and neutralizes free radicals, which are unstable molecules that can cause cellular damage and contribute to various health problems. By reducing oxidative stress, NAC helps protect cells from damage and supports overall well-being. (4)
NAC VS Glutathione:
NAC supplements and glutathione supplements are two distinct options with different roles and mechanisms of action. Hereโs a comparison between NAC and glutathione supplements:
- Precursor vs. Direct Form: NAC is a precursor to glutathione, providing the necessary building blocks for the body to produce glutathione. On the other hand, glutathione supplements directly supply the body with the active form of glutathione.โ
- Glutathione Production: NAC supports glutathione production by providing cysteine, an essential amino acid for glutathione synthesis. By increasing cysteine availability, NAC indirectly boosts glutathione levels. Glutathione supplements, on the other hand, directly deliver glutathione into the body, bypassing the need for synthesis.โ
- Absorption and Bioavailability: NAC is well-absorbed when taken orally and has good bioavailability. When taken orally, Glutathione has poor bioavailability as it gets broken down during digestion. (5)
Ultimately, choosing between NAC and glutathione supplements depends on individual needs and goals. NAC provides the advantage of supporting glutathione production and offering additional benefits beyond glutathione alone. Glutathione supplements, on the other hand, may be preferred when direct delivery of glutathione is desired, especially in cases where there may be challenges with endogenous glutathione synthesis or absorption. Consulting with a healthcare professional can help determine the most appropriate supplement for your health requirements.โ
NAC VS NAD:
In contrast to NAC, Nicotinamide Adenine Dinucleotide (NAD) plays a crucial role in cellular energy production and metabolic processes. As a coenzyme, NAD plays a role in converting nutrients into energy, particularly through its participation in cellular respiration. NAD supplements are often beneficial for supporting energy metabolism, metabolic function, and overall vitality. โ
In terms of antioxidant effects, both NAC and NAD play important roles. NAC directly exhibits antioxidant properties and contributes to glutathione regeneration, while NAD participates in redox reactions and aids in regenerating other antioxidants. Both supplements contribute to reducing oxidative stress, albeit through different mechanisms.โ
Glycine And N-acetyl Cysteine (GlyNAC):
GlyNAC, short for Glycine and N-Acetyl Cysteine, combines two powerful nutrients that work synergistically to support various aspects of health.ย
Glycine is a non-essential amino acid that plays several important roles in the body. It is involved in the production of proteins, the synthesis of DNA and RNA, and the formation of collagen, the main structural protein in connective tissues. Glycine also acts as a neurotransmitter, helping to regulate brain function and promote relaxation.โ
Together with NAC, GlyNAC creates a unique synergy that enhances each amino acidโs benefits. Studies suggest GlyNAC supplementation may positively affect aging, mitochondrial function, liver health, and cognitive function. Some research also suggests that GlyNAC may have a greater impact on glutathione production compared to NAC alone.โ
Itโs important to note that while GlyNAC shows promise, further research is still needed to fully understand its mechanisms of action and the extent of its benefits.
Is It Banned?
Itโs complicated, but as of 2024, no. In the summer of 2020, the FDA sent warning letters to companies claiming that NAC is not a dietary supplement. As a result, industry associations like the Natural Products Association (NPA), the Council for Responsible Nutrition (CRN), and the American Herbal Products Association (AHPA) filed citizen petitions. (6,7)
Their defense indicated that NAC met the definition of a dietary supplement and was marketed in the U.S. food supply since 1991 before the drug-exclusion clause became law. But instead of affirming that NAC is a lawful dietary ingredient, the FDA instead said it will โcontinues to evaluate both citizen petitions.โ (6)
So where does that leave us?
NAC may become more difficult to find as some suppliers have stopped producing it, but it is still available for purchase!
ย Benefits:
Because of its antioxidant properties, NAC can benefit health conditions caused by oxidative stress. However, in general, NACโs potential benefits are extensive. (1,8,9)
They include:
- Powerful Antioxidantโ
- Stimulants Glutathione Productionโ
- Support Healthy Lungs, Gut, Brain, Liver, And Kidneysโ
- May Reduce Symptoms Related To The Fluโ
- May Improve Fertility In Both Men And Womenโ
- It Could Help Autoimmunity By Reducing Inflammationโ
- Helps Prevent Oxidative Damageโ
As you can imagine from the FDA case, there are medicinal uses for NAC.โ (10)
This includes:
- Treat acetaminophen (Tylenol) poisoningโ
- Dissolve/loosen mucus caused by some respiratory disordersโ
- Treat polycystic ovary syndrome (PCOS)โ
Can NAC Help With COVID?
One study indicates that supplementing with 600 mg of NAC twice daily for 14 days may assist with reducing the diseaseโs progression and the need for intubation. However, more research is necessary to evaluate the benefits of NAC.* (11)
*We do not recommend taking any dietary supplement such as NAC in replacement of medical treatment for respiratory conditions like COVID-19.ย
Popular Products:
In this section, weโre going to introduce some of our popular NAC products:
How To Take Hi-Tech Pharmaceuticals NAC:
Hi-Tech Pharmaceuticals recommends taking one (1) capsule two times a day.
Customer Review By Allison: โLove taking NAC for general health and wellness. I notice a difference in my skin and overall feel better when I take it.โ Posted On 06/18/24
How To Take NOW Foods NAC:
NOW Foods suggested dosages and directions state:
- For the Tabs: Take one tablet 1 to 3 times daily.
- For the Veg Caps: Take one capsule twice daily.
Keep freshness packets in the bottle until it is empty. Keep the bottle tightly closed between uses. When exposed to air, natural color variation may occur in this product. Speckling in the capsule may occur but does not affect product quality. Store in a cool, dry place after opening.
Customer Review By Steve: โIf you have used any kind of ped, prohormones, sarms or just care about your health, you owe it to yourself to take this product or one that contains nac. I have used this product for many, many years consistently and have never even had a cold. As well as being amazing for your upper respiratory, this has kept me from getting many sinus infections, which I used to get many every year but it does wonders for your liver as well. Get some.โ Posted Onย
How To Take Swanson NAC:
Swanson recommends taking one capsule per day with water or as your healthcare provider recommends.
Customer Review By Ashley: โI love taking NAC. I noticed a difference in the first month with my overall mood and well being. I definitely recommend itโ Posted On 11/21/22
How To Take Life Extension NAC:
Life Extension recommends taking one (1) capsule one to three times daily or as a healthcare practitioner recommends.
Customer Review By J: โGreat product and great price! Love how fast we get it too!!โ Posted On 12/23/22
Wrapping Up!
This wraps up our post on NAC. Thank you for reading! And as always, if there was something that wasnโt clear, another question you want to be addressed, or if you have another idea for a blog,ย Email Us!
Looking for more to read? Check out some of our other blogs!
Warnings And Side Effects:
Hi-Tech Pharmaceuticals NAC
For adults only. Consult a physician if pregnant/nursing, taking medication, or having a medical condition. Keep out of reach of children.
NOW Foods NAC
For adults only. Consult a physician if pregnant/nursing, taking medication, or having a medical condition. Keep out of reach of children. Do not eat the freshness packets enclosed.
Swanson N-Acetyl Cysteine
For adults only. Do not take this product if you are pregnant or nursing. Consult your healthcare provider before use if you are taking any prescription medication or if you have a medical condition. Discontinue use if you experience gastrointestinal discomfort.
Keep out of reach of children. Do not use it if the seal is broken. Store in a cool, dry place.
Life Extension N-Acetyl-L-Cysteine
Those who supplement with NAC should drink 6 to 8 glasses of water daily in order to prevent cysteine renal stones. Cysteine renal stones are rare but do occur.
- KEEP OUT OF REACH OF CHILDREN
- DO NOT EXCEED RECOMMENDED DOSE
- Do not purchase if the outer seal is broken or damaged.
- When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.
Disclaimer:
โ Please noteย the intention of the information provided is for reference only. Furthermore, we are in no way providing medical advice or instruction. Instead, the information provided in this guide/blog utilizes anecdotal information and available studies/reviews. While we aim to maintain and display accurate information, we canโt guarantee it represents the latest product formulation or information. Therefore, please visit the manufacturerโs website if you have any concerns. Also, the information above does not represent our views here at Same Day Supplements. Instead, these are the manufacturersโ and usersโ views and information. Additionally, the Food and Drug Administration has not evaluated these statements. Finally, these products aim not to diagnose, treat, cure, or prevent disease or illness.
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