Metformin is commonly used to treat Type 2 diabetes, as it helps lower glucose and improve metabolism. And metabolic health status, Barzilai notes, is one of the biggest hallmarks of aging. After all, regular blood sugar spikes (i.e., lack of blood glucose control) can be a risk factor for many long-term health effects, including Alzheimer’s disease, dementia, cancer, cardiovascular disease, and so on.ย