Pairing aspirin with a probiotic may reduce stomach lining damage

โ€œAltogether, only few studies have shown beneficial effects of probiotics on NSAID-induced GI mucosal injury and Bif195 is, to our knowledge, the first bacterial biotherapeutic that has shown significant reductions in [aspirin]-induced mucosal injuries in both the stomach and the small intestine,โ€ wrote researchers from global bioscience company Chr. Hansen and the University of Copenhagen.

The research, published in the Wiley Online Libraryโ€‹, was funded by Chr. Hansen, which provided theย Bif195 and placebo capsules used in the study.

“Long-term aspirin use is associated with an increased risk of gastrointestinal damage and bleeding in the stomach and the duodenum, which precludes a considerable number of people from benefitting from the well-established protective effects for the cardiovascular system,” explained Sarah Ensel, senior clinical development scientist at Chr. Hansen and researcher in the study.

“Considering the extensive use of aspirin globally, we believe our results suggest potential for our probiotic strain Bifidobacterium breve, โ€‹Bif195 to benefit a significant number of people worldwide,” she told NutraIngredients.

Aspirin and stomach damageโ€‹

Aspiring, also known as acetylsalicylic acid (ASA), is well-established in terms of its pain-relieving, fever-reducing and cardio-protective properties. The study noted that in the U.S., it was regularly administered to more than 35 million people from 2012 to 2015, however chronic usage has been associated with an increased risk of gastrointestinal injury resulting from the formation of peptic ulcers. This has recently led to changes in the U.S. Preventive Task Force’sย recommendations on ASA use.

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