Research reveals potential role of microbiome in fertility

Women with repeated implantation failure (RIF) and recurrent pregnancy loss (RPL) experienced increased microbiome diversity with pathogenic species and a loss ofย Lactobacillusย โ€‹dominance in the lower female reproductive , according to findings published in the International Journal of Molecular Sciences.โ€‹

Findings indicated that aย Lactobacillus-dominated vaginal microbiota was beneficial for embryo implantation. In addition, pathogenic species were found in the dysbiotic vaginal microbiomes of women with both RIF and RPL including:ย Gardnerella, Prevotella, Atopobium, Megasphaeraโ€‹ย โ€‹andย Sneathia.โ€‹โ€‹

โ€œA state of microbiota dysbiosis with an overabundance of pathogenic species or the absence of Lactobacillus-dominated vaginal and endometrial microbiomes might trigger inflammation, hinder the process of embryonic implantation and interfere with early pregnancy,โ€ wrote researchers from Erasmus University Medical Center in The Netherlands.

Biotics to fight the growing prevalence of fertility issues

Commenting independently on the study, Ana Nunes, global business development director of Zinereo Pharma,ย stressed the importance of the findings for the development of biotics to fight the growing prevalence of fertility issues. Zinereo Pharma markets Fertibiome, a fertility probiotic developed in partnership with Spanish R&D firm Probisearch.

โ€œWith 48 million couples and 186 million individuals grappling with infertility, affecting about 15% of couples, there is a critical need for innovative solutions,โ€ Nunes told NutraIngredients. โ€œApproximately 15% to 30% of infertility cases being idiopathic, meaning their causes remain unknown.โ€

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