Review explores alternatives to relieve hot flashes in menopause

Curcumin, vitamin E, genistein, lactic acid bacteria, vitamin B12 and folic acid exhibit mechanisms of action around regulating inflammatory and oxidative stress, offering immunological responses and promoting estrogen production, which may relate to hot flash reduction, the review published inย Nutrientsโ€‹ย concluded.ย 

More thanย 75% of women experienceโ€‹ย hot flashes during menopause, brought on by decreased estrogen levels causing the body’s thermostat (hypothalamus) to become more sensitive to slight changes in body temperature.ย 

However, the underlying mechanisms still lack full understanding, therefore this new research compiled ingredients involved in various molecular-level processes and signalling pathways associated with hot flashes to broaden data.

Curcuminโ€‹

Curcumin could improve hot flashes in postmenopausal women, research has suggested, throughย a reduction in inflammation and oxidative stressโ€‹ย as hot flashesย have been linkedโ€‹ย to an increase in low-grade systemic inflammation.ย 

The protective effects of curcumin are linked to the inhibition of oxidative stressโ€‹ย through upregulation of proteins SIRT1 and NRF2 and downregulation of the p53/p21 central tumor suppressors pathway.

The authors also suggested that curcumin could confer benefits throughย through aryl hydrocarbon receptor (AhR) signalingโ€‹, which is important for immunological responses and inhibiting inflammation through upregulation of the protein interleukin 22 and downregulation of Th17 proinflammatory response.ย 

Vitamin Eย โ€‹

Vitamin E isย proposed to improve hot flashesโ€‹ย through a reduction in inflammation and oxidative stress.



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