The impact of modern living on microbiome profile and allergies

Humans are experiencing decreased exposure to a range of microorganisms, which can explain the difference in disparity in allergic disorders between urban and rural communities and between developed and developing countries, the researchers wrote.

โ€œIt is crucial to closely monitor the changes in microbiome profiles and the reduction in biodiversity occurring in our environment because the entire microbiome represents the โ€˜trueโ€™ environment within which we live and coexist,โ€ they explained.ย โ€œUnderstanding and documenting the microbiome profiles in both humans and the environment are crucial to safeguard mutual beneficial microorganisms and mitigate the risk of potential global epidemics of common chronicย inflammatory diseases.”ย 

Examining allergic disorders in migrantsโ€‹

Allergic conditions are higher in developed/high resourced countries and lower in developing/low resourced countries, according to the review. This is exemplified by migrants who move from developing to developed countries and experience a gradual increase in asthmatic and allergic symptoms.

โ€œImmigrants from low-risk asthma countries show significant shifts in their immune responses and distinct microbiome profiles, reinforcing the role of environmental microbial exposure in the development of asthma and allergies,โ€ the reviewers noted.

For example, in Australian-Chinese immigrants, the scientists observed a significant shift in the innate and adaptive immune response, suggesting that the increase in allergy in immigrants may result from particular taxa. After documenting differences in oropharyngeal microbiota, they found that nasalย Staphylococcus pneumoniaeโ€‹ย may play a role in developing allergic conditions in Chinese immigrants in a Western environment.

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