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The VS-01 vaginal synbiotic is formulated with an ecology of three proprietary strains of Lactobacillus crispatusโ, which were identified from over 600 candidate probiotic strains for their superior efficacy in maintaining regulated pH and promoting stability in vaginal health.
Leveraging Dr. Ravel’s discoveries, VS-01 is formulated with L. crispatusโ LUCA103, LUCA011 and LUCA009, each identified for key genomic features that confer stability in the vaginal environment, according to a press release from Seed.
“During my more than two decades of research in this field, I’ve seen countless consumer products that fail to address the unique needs of the vaginal microbiome,” Dr. Ravel said. “Many probiotics aimed at vaginal health utilize gut strains or are administered as oral supplements, ignoring that these methods do not direct the microbes from the GI tract to the vagina.ย
“I am inspired to see Seed pioneer a new frontier in vaginal health, translating my research from the lab into innovations that make a real difference in women’s lives.”
Beyond consumer applications, Seed Health is working with Dr. Ravel under LUCA Biologics to develop live biotherapeutics targeting the vaginal microbiome for unmet needs in urogenital and reproductive health.
“This launch represents the very essence of why we founded Seed: to translate pioneering microbiome discoveries into life-changing health innovations,โ said Ara Katz, Seed Health co-founder and co-CEO.
โAs a woman and a mother, it is especially meaningful to accelerate advancements in an area that has been so deprioritized and systemically overlooked. The vaginal microbiome is the next frontier in womenโs health, and VS-01 embodies its vast potentialโan entirely new paradigm of care that empowers greater agency over our bodies.โ
Scienceโ
The specific formulation was the subject of a double-blind, randomized, placebo-controlled clinical trial, the results of which will be presented at the 2024 annual conference of the Infectious Diseases Society for Obstetrics and Gynecology (IDSOG).
According to Seed, VS-01 established an optimal vaginal microbiome dominated by L. crispatusโ in 90% of participants with a non-optimal vaginal microbiome within 21 days of use.
In addition, the VS-01 suppository tablet rapidly increased abundance of L. crispatusโ in the vaginal environment. In contrast, no strains from a leading oral probiotic for vaginal health were detected in the vagina by the end of the study.
The company also claims that its proprietary SMART Tablet provides an extended-release profile that is superior to both placebo and a fast-release vaginal capsule with the same strains.
Seed โ
Widely known for its consumer health brand Seed, the company currently has two consumer products: DS-01 Daily Synbiotic for adults and PDS-08, a pediatric synbiotic.
DS-01, a broad-spectrum probiotic with 24 genetically distinct microorganisms across 12 species, was developed with Dr. Gregor Reid, Seed Health’s scientific advisor, past-president of the International Scientific Association of Probiotics and Prebiotics (ISAPP), and former chair of the United Nations World Health Organization Expert Panel that authored the global scientific definition of probiotics. The product won the NutraIngredients-USA Award for probiotic product of the year in 2022.
PDS-08 was launched in 2022 and is a first multi-strain synbiotic formulated with L. salivariusโ LS01, Bifidobacterium breveโ B632, B. breveโ BR03, B. lactisโ BPL1, B. longumโ ES1, L. caseiโ BPL4, L. rhamnosusโ GG, L. acidophilusโ NCFM and B. animalisโ subsp. lactisโ Bi-07.
Beyond the consumer products, Seed also has a biotech platform for microbiome science.
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